Also, there was a significant (p < 0.05) increase in aspartate aminotransferase and alkaline phosphatase activity.

The results revealed a significant (p < 0.05) increase in alanine aminotransferase activity in a dose-dependent manner when compared with the control. Six weeks after the administration of calcium hypochlorite, blood was collected from the jugular vein to assess liver function, lipid profiles and for markers of oxidative stress. Groups 2, 3 and 4 received 0.0375 g, 0.375 g and 0.75 g of calcium hypochlorite per 10 litres of drinking water for six weeks respectively. Group 1, which served as the control, received 10 mL/kg body weight of physiological saline. Thirty-two healthy birds were used they were grouped into four groups of eight. It was carried out in order to ascertain probable toxicity associated with prolonged exposure to calcium hypochlorite. This study was designed to investigate the effects of prolonged oral administration of calcium hypochlorite in the drinking water of commercial cockerels.

IIDepartments of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Nigeria IFederal College of Animal Health and Production Technology, Moor Plantation, Nigeria The effects of prolonged oral administration of the disinfectant calcium hypochlorite in Nigerian commercial cockerels

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